Basic Information
| ID | DRAMP21331 |
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| Sequence | WKLKWKLKWKLK |
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| Length | 12 |
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| Name | KLK (Derived from PMAP-36) |
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| Source | synthetic construct |
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| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram- |
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| Pathogen | [Ref.31276398] Gram-positive bacteria:Staphylococcus aureus 29213 (MIC=2 μM), Staphylococcus aureus 25923 (MIC=2 μM), Staphylococcus epidermidis 12228 (MIC=2 μM), Staphylococcus aureus 11011 (MIC=2 μM);##Gram-negative bacteria: Escherichia coli 25922 (MIC=4 μM), Escherichia coli 1005 (MIC=4 μM), Staphylococcus typhi (MIC=2 μM), Escherichia coli 20411 (MIC=2 μM), Acinetobacter baumannii AB1901 (MIC=2 μM), Acinetobacter baumannii AB1902 (MIC=4 μM), Pseudomonas aeruginosa 25349 (MIC=4 μM). |
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| Hemolytic Activity | [Ref.31276398] MHC=128μM. The minimum hemolytic concentration (MHC) is measured as the lowest concentration of the peptides that caused 5% hemolysis of human red blood cells (hRBCs). |
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| Cytotoxicity | [Ref.31276398] The cell viability of the murine macrophage cell line RAW264.7 induced by KLK is 103.3%, 100.2%, 100.5%, 97.8%, 99.1%, 96.4%, 98.4% and 44.5% at peptide concentrations of 1, 2, 4, 8, 16, 32, 64 and 128 μM |
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| N-terminal Modification | Free |
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| C-terminal Modification | Amidation |
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| Linear/Cyclic/Branched | Linear |
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| Uniprot |
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| PDB |
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| 3D View | |
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| PDB Download | Download PDB Predicted by Alphafold2 |
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| PubMed ID | 31276398 |
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