Basic Information

IDDRAMP21367
SequenceFLGALWNVKKSVF
Length13
Name[Lys]9-VmCT1-NH2 (Derived from VmCT1)
Sourcesynthetic construct
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Antifungal
Pathogen[Ref.31181304] Gram-positive bacteria: Micrococcus luteus A270 (MIC=0.4 μmol/L);##Fungi: Candida albicans MDM8 (MIC=50 μmol/L)
Hemolytic Activity[Ref.31181304] 0% hemolysis at 100 μmol/L against human red blood cells
Cytotoxicity[Ref.31181304] The cell viability of MCF-7 cells induced by [Lys9]-VmCT1-NH2 is 120%, 120%, 105%, 110%, 110%, 108%, 120% and 120% at peptide concentrations of 0.8, 1.6, 3.1, 12.5, 25, 50 and 100 μM.
N-terminal ModificationFree
C-terminal ModificationAmidation
Linear/Cyclic/BranchedLinear
Uniprot
PDB
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PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID31181304

Physicochemical Properties

Residues13
SequenceFLGALWNVKKSVF
Molecular Weight1508.804
Grand Average of Hydropathy0.769
Isoelectric Point10.003
Charge at pH 7.41.552
Secondary StructureHelix: 0.538, Turn: 0.231, Sheet: 0.231
Instability Index28.192
Aromaticity0.231

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