Basic Information
| ID | DRAMP29052 |
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| Sequence | FLGALFKVASKLVPAAICSISKKC |
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| Length | 24 |
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| Name | Brevinin-1GHd |
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| Source | Sylvirana guentheri (Gunther's frog) (Rana guentheri) |
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| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram- |
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| Pathogen | [Ref.32347293] Gram-positive bacteria: S. aureus (MIC = 2 μM/MBC= 4 µM), MRSA(MIC = 4 μM/MBC = 4µM); ##Gram-negative: E. coli(MIC = 8 μM/MBC = 8 µM), P. aeruginosa(MIC = 32 μM/MBC = 32µM); ##Fungi: C. albicans(MIC = 4 μM/MBC = 8µM） |
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| Hemolytic Activity | [Ref.32347293] Brevinin-1GHd displayed 13% hemolysis on horse red blood cells at its highest MIC/MBC value of the tested bacteria P. aeruginosa (32 µM). However, when the concentration increased above 64 μM, the hemolytic activity of Brevinin-1GHd also gradually increased. At the concentration of 64, 128, 256 and 512 μM, it displayed about 36%, 64%, 83% and 108% hemolysis. |
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| Cytotoxicity | [Ref.32347293]Brevinin-1GHd showed significant cytotoxicity toward human HMEC-1 and HaCaT cells at concentrations of 0.00001 and 0.0001 M, respectively. Brevinin-1GHd induced one cell viability of 56% on HMEC-1 and the other cell viability of 75% on HaCat. |
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| N-terminal Modification | Free |
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| C-terminal Modification | Free |
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| Linear/Cyclic/Branched | Cyclic |
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| Uniprot |
A0A6M4CA40 |
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| PDB |
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| 3D View | |
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| PDB Download | Download PDB Predicted by Alphafold2 |
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| PubMed ID | 32347293 |
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