Basic Information

IDDRAMP00749
SequenceELCEKASKTWSGNCGNTGHCDNQCKSWEGAAHGACHVRNGKHMCFCYFNC
Length50
NameDefensin-like protein 1 (Dm-AMP1; Plant defensin)
SourceDahlia merckii (Bedding dahlia)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Antifungal
PathogenGram-positive bacterium: Bacillus subtilis (IC50=150 µg/mL).##Medium A: Botrytis cinerea (IC50=12 µg/ml), Cladosporium sphaerospermum (IC50=3 µg/ml), Fusarium culmorum (IC50=5 µg/ml), Leptosphaeria maculans (IC50=1.5 µg/ml), Penicillium digitatum (IC50=2 µg/ml), Trichoderma viride (IC50>100 µg/ml), Septoria tritiei (IC50=1 µg/ml), Verticilium albo-atrum (IC50=4 µg/ml). NOTE: Medium B = 1/2 strength potato dextrose broth.##Medium B: Botrytis cinerea (IC50>100 µg/ml), Cladosporium sphaerospermum (IC50=12 µg/ml), Fusarium culmorum (IC50=8 µg/ml), Leptosphaeria maculans (IC50=15 µg/ml), Penicillium digitatum (IC50=70 µg/ml), Trichoderma viride (IC50>100 µg/ml), Septoria tritiei (IC50=4 µg/ml), Verticilium albo-atrum (IC50>100 µg/ml).##NOTE: Medium B = Medium A supplemented with 1 mM CaCl2 and 50 mM KCI.
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot P0C8Y4
PDB
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PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID13129623, 7628617, 8663029, 17216480

Physicochemical Properties

Residues50
SequenceELCEKASKTWSGNCGNTGHCDNQCKSWEGAAHGACHVRNGKHMCFCYFNC
Molecular Weight5525.146
Grand Average of Hydropathy-0.69
Isoelectric Point7.799
Charge at pH 7.40.608
Secondary StructureHelix: 0.140, Turn: 0.280, Sheet: 0.180
Instability Index5.59
Aromaticity0.1

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