Basic Information

IDDRAMP01017
SequenceCIGNGGRCNENVGPPYCCSGFCLRQPNQGYGVCRNR
Length36
NameAntimicrobial peptide 2 (MJ-AMP2; Plant defensin)
SourceMirabilis jalapa (Garden four-o'clock)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Antifungal
PathogenFungi: Alternaria brassicola (MIC=6 µg/ml), Ascochyta pisi (MIC=6 µg/ml), Botrytis cinerea (MIC=2 µg/ml), Cercospora beticola (MIC=2 µg/ml), Colletotrichum lindemuthianum (MIC=1 µg/ml), Fusarium culmorum (MIC=3 µg/ml), Fusarium oxysporum f.sp.pisi (MIC=5 µg/ml), Fusarium oxysporum f.sp.lycopersici (MIC=10 µg/ml), Nectria haematococca (MIC=0.5 µg/ml), Phoma betae (MIC=6 µg/ml), Pyrenophora tritici-repentis (MIC=20 µg/ml), Pyricularia oryzae (MIC=0.5 µg/ml), Rhizoctonia solani (MIC=15 µg/ml), Verticillium dahliae (MIC=0.5 µg/ml), Venturia inequalis (MIC=1 µg/ml).##Gram-positive bacteria: Bacillus megaterium (MIC=2 µg/ml), Sarcina lutea (MIC=50 µg/ml).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNo cytotoxicity information found
N-terminal ModificationCyclization of a N-terminal Cys residue (forming a disulfide bond)
C-terminal ModificationFree
Linear/Cyclic/BranchedCyclic
Uniprot P25404
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID1733929, 7647302

Physicochemical Properties

Residues36
SequenceCIGNGGRCNENVGPPYCCSGFCLRQPNQGYGVCRNR
Molecular Weight3893.38
Grand Average of Hydropathy-0.625
Isoelectric Point8.688
Charge at pH 7.42.406
Secondary StructureHelix: 0.194, Turn: 0.444, Sheet: 0.056
Instability Index27.625
Aromaticity0.083

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