Basic Information
| ID | DRAMP01222 |
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| Sequence | GFMDTAKNVAKNVAVTLIDKLRCKVTGGC |
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| Length | 29 |
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| Name | Palustrin-2AJ1 (PL2AJ1; Frogs, amphibians, animals) |
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| Source | Amolops jingdongensis (Chinese torrent frog) |
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| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram- |
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| Pathogen | [Ref.21816202]Gram-positive bacteria: Staphylococcus aureus ATCC25923 (MIC=20 µM), Enterococcus faecalis ATCC29212 (MIC=20 µM);##Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=13 µM), Bacillus pyocyaneus CMCCB1010 (MIC=20 µM), Pseudomonas aeruginosa ATCC27853 (MIC=33 µM), Bacillus dysenteriae (MIC=50 µM). |
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| Hemolytic Activity | [Ref:21816202] IC50=135 μM against human and rabbit erythrocytes |
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| Cytotoxicity | [Ref.21816202] Cytotoxicity: the K562 (IC50=58μM) and HT29 mammalian cell lines(IC50=57μM). |
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| N-terminal Modification | Free |
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| C-terminal Modification | Cyclization (Cys23 and Cys29) |
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| Linear/Cyclic/Branched | Cyclic |
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| Uniprot |
G3ETQ3 |
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| PDB |
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| 3D View | |
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| PDB Download | Download PDB Predicted by Alphafold2 |
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| PubMed ID | 21816202 |
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