Basic Information

IDDRAMP01586
SequenceGLFKVLGSVAKHLLPHVAPIIAEKL
Length25
NameCaerin-1.19 (Frogs, amphibians, animals)
SourceLitoria gracilenta (Dainty green tree frog)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-,Antiviral
Pathogen[Ref.16554081]Gram-positive bacteria: Bacillus cereus (MIC=50 µg/ml), Leuconostoc lactis (MIC=3 µg/ml), Listeria innocua (MIC=12 µg/ml), Micrococcus luteus (MIC=25 µg/ml), Staphylococcus aureus Strain ATCC 25923 (MIC=12 µg/ml), Staphylococcus aureus Strain ATCC 29213 (MIC=12 µg/ml), Staphylococcus epidermidis (MIC=12 µg/ml), Streptococcus uberis (MIC=25 µg/ml);##Gram-negative bacteria: Pasteurella multocida (MIC=50 µg/ml).##[Ref.26026377]Virus:HIV: inhibition of HIV Pseudovirus (PsV) infection in CD4+ T cells(IC50=2.5 µM).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNo cytotoxicity information found in the reference(s) presented
N-terminal ModificationFree
C-terminal ModificationAmidation
Linear/Cyclic/BranchedLinear
Uniprot P0C2A8
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID26026377, 16554081

Physicochemical Properties

Residues25
SequenceGLFKVLGSVAKHLLPHVAPIIAEKL
Molecular Weight2651.239
Grand Average of Hydropathy0.896
Isoelectric Point9.703
Charge at pH 7.41.624
Secondary StructureHelix: 0.440, Turn: 0.200, Sheet: 0.360
Instability Index12.204
Aromaticity0.04

Similar Structure Search

Candidates based on structure

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