Basic Information
| ID | DRAMP01639 |
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| Sequence | GLWSTIKNVGKEAAIAAGKAALGAL |
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| Length | 25 |
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| Name | Dermaseptin-1 (DShypo01, DPh-1; Frogs, amphibians, animals) |
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| Source | Phyllomedusa hypochondrialis (Orange-legged leaf frog) |
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| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiprotozoal |
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| Pathogen | [Ref.16963159]Gram-positive bacteria: Micrococcus luteus A270 (MIC=6 µM), Staphylococcus aureus ATCC 6538 (MIC=6 µM);##Gram-negative bacteria: Escherichia coli SBS 363 (MIC=6 µM), Pseudomonas aeruginosa ATCC 14502 (MIC=6.6 µM). |
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| Hemolytic Activity | [Ref:16844081]Non-hemolytic activity upto 53 μM against human red blood cells;##[Ref.16963159]Non-hemolytic activity at 6 μM against erythrocytes |
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| Cytotoxicity | [Ref.16844081]No cytotoxicity information found##[Ref.16963159]No cytotoxicity information found |
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| N-terminal Modification | Free |
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| C-terminal Modification | Amidation |
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| Linear/Cyclic/Branched | Linear |
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| Uniprot |
P84596 |
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| PDB |
|
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| 3D View | |
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| PDB Download | Download PDB Predicted by Alphafold2 |
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| PubMed ID | 16844081, 16963159 |
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