Basic Information

IDDRAMP01780
SequenceFLSGIVGMLGKLF
Length13
NameTemporin-SHa (Temporin-1Sa; Frogs, amphibians, animals)
SourcePelophylax saharica (North Africa)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
PathogenGram-positive bacteria: Staphylococcus aureus (MIC=3 µM), Bacillus megaterium (MIC=2 µM);##Gram-negative bacterium: Escherichia coli (MIC=10 µM).##Yeast: Candida albicans (MIC=16 µM).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity[Ref.31614561]Display cytotoxic against human gastric cells(N87 cell:IC50=1558 ± 324μM)
N-terminal ModificationFree
C-terminal ModificationAmidation
Linear/Cyclic/BranchedLinear
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID31614561

Physicochemical Properties

Residues13
SequenceFLSGIVGMLGKLF
Molecular Weight1381.724
Grand Average of Hydropathy1.669
Isoelectric Point8.75
Charge at pH 7.40.555
Secondary StructureHelix: 0.538, Turn: 0.308, Sheet: 0.308
Instability Index-23.423
Aromaticity0.154

Similar Structure Search

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