Basic Information

IDDRAMP02269
SequenceGVLSNVIGYLKKLGTGALNAVLKQ
Length24
NameAntimicrobial peptide PGQ (PGQ; Frogs, amphibians, animals)
SourceXenopus laevis (African clawed frog)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
PathogenGram-negative bacteria: Escherichia coli (MIC=62-250 µg/ml), K. Pneumonae (MIC=125-250 µg/ml), Pseudomonas aeruginosa (MIC=250-500 µg/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=250-500 µg/ml), Streptococcus faecalis (MIC=250-500 µg/ml).##Yeast: Candida albicans (MIC=250-500 µg/ml).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot P39080
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID1717472

Physicochemical Properties

Residues24
SequenceGVLSNVIGYLKKLGTGALNAVLKQ
Molecular Weight2456.921
Grand Average of Hydropathy0.546
Isoelectric Point10.001
Charge at pH 7.42.547
Secondary StructureHelix: 0.417, Turn: 0.292, Sheet: 0.292
Instability Index-5.329
Aromaticity0.042

Similar Structure Search

Candidates based on structure

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