Basic Information

IDDRAMP03017
SequenceFMPIIGRLMSGSL
Length13
NameVESP-VB1 (Insects, animals)
Sourcevespine wasps Vespa bicolor
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
Pathogen[Ref.18723059] Gram-negative bacterium: Escherichia coli ATCC25922(MIC=7.5μg/ml), Escherichia coli 23A(MIC=7.5μg/ml), Escherichia coli 27A(MIC=15.0μg/ml), Pseudemonas aeruginosa 3A(MIC=3.75μg/ml), Pseudemonas aeruginosa 7A(MIC=3.75μg/ml), ;## Gram-positive bacterium: Staphylococcus aureus ATCC2592(MIC=1.9μg/ml), Staphylococcus aureus 6A(MIC=3.75μg/ml), Staphylococcus aureus 15A(MIC=1.0μg/ml);## Fungus: Candida albicans ATCC2002(MIC=30.0μg/ml)
Hemolytic Activity[Ref.18723059] VESP-VB1 had a little hemolytic activity of 10.2% against rabbit red blood cells, and of 3.2% against human red blood cells with peptide concentration up to 200 μg/ml
CytotoxicityNo cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationFree
Linear/Cyclic/BranchedLinear
Uniprot
PDB
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PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID18723059

Physicochemical Properties

Residues13
SequenceFMPIIGRLMSGSL
Molecular Weight1421.77
Grand Average of Hydropathy1.131
Isoelectric Point9.75
Charge at pH 7.40.557
Secondary StructureHelix: 0.385, Turn: 0.385, Sheet: 0.308
Instability Index76.831
Aromaticity0.077

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