Basic Information

IDDRAMP03419
SequenceVTCYCRRTRCGFRERLSGACGYRGRIYRLCCR
Length32
NameNeutrophil antibiotic peptide NP-1 (RatNP-1; Rodents, mammals, animals)
SourceRattus norvegicus (Rat)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
PathogenGram-positive bacterium: Staphylococcus aureus 502A [18 h] (MIC<100 cfu/ml);##Gram-negative bacterium: Escherichia coli ML-35 [18 h] (MIC<100 cfu/ml).##Fungi: Candida albicans 820 [18 h] (MIC<100 cfu/ml), Cryptococcus neoformans A-383 [18 h] (MIC=1.7 x 102 cfu/ml).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNo cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationFree
Linear/Cyclic/BranchedCyclic
Uniprot Q62716
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID2543629, 7594610

Physicochemical Properties

Residues32
SequenceVTCYCRRTRCGFRERLSGACGYRGRIYRLCCR
Molecular Weight3835.523
Grand Average of Hydropathy-0.494
Isoelectric Point9.987
Charge at pH 7.47.37
Secondary StructureHelix: 0.250, Turn: 0.156, Sheet: 0.125
Instability Index20.137
Aromaticity0.125

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