Basic Information

IDDRAMP03692
SequenceACQFWSCNSSCISRGYRQGYCWGIQYKYCQCQ
Length32
NameDefensin-1 (Cll-dlp; Arthropods, animals)
SourceCentruroides limpidus limpidus (Mexican scorpion)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
Pathogen[Ref.15197474]Gram-positive bacteria: Bacillus subtilis (MIC>50 µg/ml), Staphylococcus aureus ATCC 25923 (MIC>50 µg/ml);##Gram-negative bacteria: Escherichia coli DH5a (MIC>50 µg/ml), Klebsiella pneumoniae ATCC 13883 (MIC>50 µg/ml).##NOTE: Liquid growth inhibition assay.
Hemolytic Activity[Swiss_Prot Entry Q6GU94]Non-hemolytic activity against human erythrocytes
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot Q6GU94, P83738
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID15197474

Physicochemical Properties

Residues32
SequenceACQFWSCNSSCISRGYRQGYCWGIQYKYCQCQ
Molecular Weight3821.308
Grand Average of Hydropathy-0.522
Isoelectric Point8.654
Charge at pH 7.42.448
Secondary StructureHelix: 0.281, Turn: 0.250, Sheet: 0.031
Instability Index35.975
Aromaticity0.219

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