Basic Information

IDDRAMP04048
SequenceRRLCRIVVIRVCRR
Length14
NameBacR (cyclic derivative of bactenecin)
SourceSynthetic construct
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
PathogenGram-negative bacteria: Escherichia coli K-12 (MIC=2 µg/ml), Pseudomonas aeruginosa K799 (MIC=4 µg/ml), Salmonella typhimurium 14028s (MIC=4 µg/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=64 µg/ml), Staphylococcus epidermidis C621 (MIC=8 µg/ml), Enterococcus faecalis ATCC 29212 (MIC=32 µg/ml), Listeria monocytogenes (MIC<0.125 µg/ml), Corynebacterium xerosis (MIC=1 µg/ml), Streptococcus pyogenes ATCC 19615 (MIC=8 µg/ml), S. mitis (MIC=0.5 µg/ml), Streptococcus pneumoniae ATCC 49619 (MIC>64 µg/ml).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNo cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationFree
Linear/Cyclic/BranchedCyclic
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID10223951

Physicochemical Properties

Residues14
SequenceRRLCRIVVIRVCRR
Molecular Weight1798.281
Grand Average of Hydropathy0.243
Isoelectric Point12
Charge at pH 7.45.508
Secondary StructureHelix: 0.429, Turn: 0.000, Sheet: 0.071
Instability Index85.05
Aromaticity0

Similar Structure Search

Candidates based on structure

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