| ID | DRAMP20945 |
|---|---|
| Sequence | KWKLFKKIFKRIVQRIKDFLRN |
| Length | 22 |
| Name | Recombinant Cecropin A (1–8)–LL37 (17–30) (C–L) |
| Source | Synthetic construct |
| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram- |
| Pathogen | [Ref.29925795] Gram-negative bacteria: Escherichia coli CVCC 245 (MIC=7.2 ± 0.14 μg/mL);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=2.2 ± 0.05 μg/mL),L. mono. CVCC 1599 (MIC=2.1 ± 0.03 μg/mL) |
| Hemolytic Activity | [Ref.29925795] 50% hemolysis at 221 ± 3.45μg/ml against sheep red blood cells |
| Cytotoxicity | [Ref.29925795] No cytotoxicity information found |
| N-terminal Modification | Free |
| C-terminal Modification | Free |
| Linear/Cyclic/Branched | Linear |
| Uniprot | |
| PDB | |
| 3D View | |
| PDB Download | Download PDB Predicted by Alphafold2 |
| PubMed ID | 29925795 |
Physicochemical Properties
| Residues | 22 |
|---|---|
| Sequence | KWKLFKKIFKRIVQRIKDFLRN |
| Molecular Weight | 2905.576 |
| Grand Average of Hydropathy | -0.664 |
| Isoelectric Point | 11.764 |
| Charge at pH 7.4 | 7.543 |
| Secondary Structure | Helix: 0.455, Turn: 0.045, Sheet: 0.091 |
| Instability Index | 6.2 |
| Aromaticity | 0.182 |