Basic Information

IDDRAMP00171
SequenceLIDHLGAPRWAVDTILGAIAVGNLASWVLALVPGPGWAVKAGLATAAAIVKHQGKAAAAAW
Length61
NameLactocyclicin Q (Bacteriocin)
SourceLactococcus sp. strain QU 12 (Gram-positive bacteria)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
PathogenGram-positive bacteria: Lactococcus sp.strain QU 12 (MIC=34.3 µM), Lactococcus lactis subsp.lactis JCM 7638 (MIC=0.141 µM), L. lactis subsp.lactis ATCC 19435 (MIC=0.141 µM), L. lactis subsp.lactis IL1403 (MIC=0.141 µM), L. lactis QU 1 (MIC=0.141 µM), L. lactis subsp.cremoris ATCC 19275 (MIC=0.283 µM), Lactococcus raffinolactis JCM 5706 (MIC=0.71 µM), Lactobacillus sakei subsp.sakei JCM 1157 (MIC=0.015 µM), Lactobacillus casei subsp.casei JCM 1134 (MIC=2.27 µM), Leuconostoc brevis JCM 1059 (MIC=1.14 µM), L. acidophilus JCM 1132 (MIC=2.86 µM), L. coryniformis subsp.coryniformis JCM 1164 (MIC=2.86 µM), L. kimchii JCM 10707 (MIC=0.71 µM), L. mesenteroides subsp.mesenteroides JCM 6124 (MIC=1.03 µM), Weissella cibaria JCM 12495 (MIC=0.71 µM), Pediococcus pentosaceus JCM 5885 (MIC=0.55 µM), P. pentosaceus JCM 5890 (MIC=2.86 µM), P. acidilactici JCM 8797 (MIC=2.86 µM), P. dextrinicus JCM 5887 (MIC=0.141 µM), Enterococcus faecium JCM5804 (MIC=0.71 µM), E. hirae ATCC 10541 (MIC=0.71 µM), E. durans NBRC 100479 (MIC=0.71 µM), E. faecalis JCM 5803 (MIC=0.26 µM), Streptococcus salivarius JCM 5707 (MIC=22.9 µM), S. bovis JCM 5802 (MIC=22.9 µM), Bacillus coagulans JCM 2257 (MIC=0.015 µM), B. circulans JCM 2504 (MIC=0.031 µM), B. subtilis JCM 1465 (MIC=0.064 µM), B. cereus JCM 2152 (MIC=11.4 µM), Micrococcus luteus IFO 12708 (MIC=5.7 µM), Listeria innocua ATCC 33090 (MIC=1.03 µM), L. monocytogenes ATCC BAA-679 (MIC=1.03 µM), Staphylococcus aureus subsp.aureus ATCC 12600 (MIC=91.6 µM); Gram-negative bacteria: Escherichia coli JM109 (MIC=34.3 µM), E. coli NBRC 3301 (MIC=17.3 µM).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNo cytotoxicity information found
N-terminal ModificationCyclization (N termini to C termini)
C-terminal ModificationCyclization (C termini to N termini)
Linear/Cyclic/BranchedCyclic
Uniprot B9ZZY0
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID19139222, 21948835

Physicochemical Properties

Residues61
SequenceLIDHLGAPRWAVDTILGAIAVGNLASWVLALVPGPGWAVKAGLATAAAIVKHQGKAAAAAW
Molecular Weight6078.076
Grand Average of Hydropathy0.826
Isoelectric Point9.7
Charge at pH 7.41.624
Secondary StructureHelix: 0.344, Turn: 0.197, Sheet: 0.393
Instability Index8.943
Aromaticity0.066

Similar Structure Search

Candidates based on structure

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