Basic Information
| ID | DRAMP02294 |
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| Sequence | GILDTLKQFAKGVGKDLVKGAAQGVLSTVSCKLAKTC |
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| Length | 37 |
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| Name | Gaegurin-4 (Gaegurin 4; GGN4; Frogs, amphibians, animals) |
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| Source | Glandirana rugosa (Japanese wrinkled frog) (Rana rugosa) |
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| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiprotozoal |
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| Pathogen | [Ref.7999137]Gram-positive bacteria: Micrococcus luteus (MIC=2.5 µg/ml), Staphylococcus epidermidis (MIC=10 µg/ml), Bacillus subtilis (MIC=10 µg/ml);##Gram-negative bacteria: Klebsiella pneumoniae (MIC=25 µg/ml), Shigella dysentariae (MIC=25 µg/ml), Pseudomonas putida (MIC=100 µg/ml), Pseudomonas aeruginosa (MIC=100 µg/ml), Eshchericia coli (MIC=75 µg/ml);##Fungi: Saccharomyces cerevisiae (MIC=200 µg/ml), Candida albicans (MIC=200 µg/ml), Salmonella typhimurium (MIC=200 µg/ml), Proteus mirabilis (MIC>200 µg/ml), Serratia marcescens (MIC>200 µg/ml). |
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| Hemolytic Activity | [Ref.7999137] It has 0.50% hemolytic activity at 0.1 μg/ml, 0.74% hemolytic activity at 1 μg/ml, 0.78% hemolytic activity at 10 μg/ml, 1.67% hemolytic activity at 100 μg/ml against human red blood cells |
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| Cytotoxicity | No cytotoxicity information found |
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| N-terminal Modification | Free |
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| C-terminal Modification | Cyclization (Cys31 and Cys37) |
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| Linear/Cyclic/Branched | Cyclic |
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| Uniprot |
P80398, Q91328, Q98TA6 |
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| PDB |
2G9L |
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| 3D View | |
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| PDB Download | Download PDB Predicted by Alphafold2 |
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| PubMed ID | 7999137, 17141187, 11004488 |
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