Basic Information

IDDRAMP03405
SequenceGLLRKGGEKIGEKLKKIGQKIKNFFQKLVPQPE
Length33
NamemCRAMP-1 (mouse cathelin-related antimicrobial peptide 1; cathelicidin; Rodents, mammals, animals
SourceMus musculus (Mouse)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
PathogenGram-negative bacteria: Escherichia coli ATCC 25922 (MIC=1 µM), Escherichia coli ML35 (MIC=2 µM), Escherichia coli D21 (MIC=8 µM), Pseudomonas aeruginosa ATCC 27853 (MIC=4 µM), Serratia marcescens ATCC 8100 (MIC=4 µM);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=32 µM), Staphylococcus aureus Cowan I (MIC=32 µM), Staphylococcus aureus (MRSA) (MIC>64 µM), Staphylococcus aureus (MRSA) (MIC=64 µM), Staphylococcus epidermidis ATCC 12228 (MIC=16 µM), Streptococcus faecalis ATCC 29212 (MIC=16 µM), Bacillus megaterium Bm11 (MIC=4 µM).##Fungi: Candida albicans (MIC>64 µM), Cryptococcus neoformans (MIC=16 µM).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot P51437, Q0VB78
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID9148921, 8706928

Physicochemical Properties

Residues33
SequenceGLLRKGGEKIGEKLKKIGQKIKNFFQKLVPQPE
Molecular Weight3750.48
Grand Average of Hydropathy-0.815
Isoelectric Point10.219
Charge at pH 7.45.543
Secondary StructureHelix: 0.303, Turn: 0.242, Sheet: 0.212
Instability Index12.342
Aromaticity0.061

Similar Structure Search

Candidates based on structure

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