Basic Information
| ID | DRAMP20868 |
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| Sequence | KFKKLFKKLSPVIGKEFKRIVERIKRFLR |
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| Length | 29 |
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| Name | H4 |
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| Source | Synthetic construct |
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| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram- |
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| Pathogen | [Ref.29910626] Gram-positive bacteria: Staphylococcus aureus ATCC 29213 (MIC=20 μM), Staphylococcus aureus ATCC 33591 (MIC=10 μM), Staphylococcus aureus ATCC 43300 (MIC=10 μM), Staphylococcus aureus ATCC BAA41 (MIC=10 μM), Enterococcus faecalis ATCC 19433 (MIC=15 μM), Enterococcus faecalis ATCC BAA2365 (MIC=5 μM), Staphylococcus epidermidis ATCC 12228 (MIC=10 μM), Enterococcus faecium ATCC BAA2316 (MIC=5 μM);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=10 μM), Pseudomonas aeruginosa ATCC 27853 (MIC=20 μM), Acinetobacter baumannii ATCC 19606 (MIC=10 μM), Klebsiella pneumoniae ATCC 13883 (MIC=2.5 μM), Pseudomonas aeruginosa ATCC BAA2114 (MIC=25 μM), Escherichia coli ATCC BAA2452 (MIC=10 μM) |
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| Hemolytic Activity | [Ref.29910626] 0% haemolysis at 5 μM, 0% haemolysis at 10 μM, 0% haemolysis at 25 μM, 0% haemolysis at 40 μM, 0% haemolysis at 55 μM, 0% haemolysis at 75 μM, 0% haemolysis at 80 μM, 2.1% haemolysis at 100 μM against human red blood cells |
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| Cytotoxicity | [Ref.29910626] IC50 = 61.9±0.18 μM against HEK293.## IC50 = 64.9±1.01 μM against Vero. |
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| N-terminal Modification | Free |
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| C-terminal Modification | Free |
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| Linear/Cyclic/Branched | Linear |
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| Uniprot |
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| PDB |
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| 3D View | |
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| PDB Download | Download PDB Predicted by Alphafold2 |
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| PubMed ID | 29910626 |
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