Basic Information
| ID | DRAMP21402 |
|---|
| Sequence | KFKKLFKKLSPVFKRIVQRIKDFLR |
|---|
| Length | 25 |
|---|
| Name | B1 (Derived from LL-37 and BMAP-27) |
|---|
| Source | synthetic construct |
|---|
| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram- |
|---|
| Pathogen | [Ref.31118709] Gram-positive bacteria:Staphylococcus aureus ATCC 29213(MIC=20μM), Staphylococcus aureus ATCC 33591(MIC=20μM), Staphylococcus aureus ATCC 43300(MIC=20μM), Staphylococcus aureus ATCC BAA-41(MIC=20μM);##Gram-negative bacteria: Escherichia coli 25922 (MIC=20μM), Escherichia coli 35218 (MIC=20μM), Pseudomonas aeruginosa BAA-2114 (MIC=10μM) |
|---|
| Hemolytic Activity | [Ref.31118709] 0% hemolysis at 10μM, 8% hemolysis at 25μM, 19% hemolysis at 50μM, 23% hemolysis at 75μM, 30% hemolysis at 100μM, 38% hemolysis at 125μM, 40% hemolysis at 150μM, 43% hemolysis at 175μM, 50% hemolysis at 200μM against human blood cells. |
|---|
| Cytotoxicity | [Ref.31118709] The cell viability of HEK293 mammalian cell line induced by B1 is 87.0%, 67.1%, 52.3%, 54.3%, 50.6% and 50% at peptide concentrations of 10, 20, 40, 60, 80 and 100 μM. |
|---|
| N-terminal Modification | Free |
|---|
| C-terminal Modification | Free |
|---|
| Linear/Cyclic/Branched | Linear |
|---|
| Uniprot |
|
|---|
| PDB |
|
|---|
| 3D View | |
|---|
| PDB Download | Download PDB Predicted by Alphafold2 |
|---|
| PubMed ID | 31118709 |
|---|
