Basic Information

IDDRAMP03233
SequenceGFFGKMKEYFKKFGASFKRRFANLKKRL
Length28
NameM-zodatoxin-Lt5a (M-ZDTX-Lt5a; Latarcin-5, Ltc-5; spiders, Arthropods, animals)
SourceLachesana tarabaevi (Spider)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
Pathogen[Ref.16735513]Gram-positive bacteria: Arthrobacter globiformis VKM Ac-1112 (MIC=1.1 µM), Bacillus subtilis VKM B-501 (MIC=0.6 µM);##Gram-negative bacteria: Escherichia coli DH5-alpha (MIC=0.6 µM), Escherichia coli MH1 (MIC=0.6 µM), Pseudomonas aeruginosa PAO1 (MIC=18 µM);##Fungi: Pichia pastoris GS115 (MIC>37 µM), Saccharomyces cerevisiae Y190 (MIC>37 µM).
Hemolytic Activity[Ref.16735513]20% hemolytic activity at 40 μM against rabbit erythrocytes
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot Q1ELU9
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID16735513

Physicochemical Properties

Residues28
SequenceGFFGKMKEYFKKFGASFKRRFANLKKRL
Molecular Weight3431.109
Grand Average of Hydropathy-0.757
Isoelectric Point11.235
Charge at pH 7.48.538
Secondary StructureHelix: 0.321, Turn: 0.179, Sheet: 0.214
Instability Index45.196
Aromaticity0.25

Similar Structure Search

Candidates based on structure

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