Basic Information
| ID | DRAMP02802 |
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| Sequence | AREASKSLIGTASCTCRRAWICRWGERHSGKCIDQKGSTYRLCCRR |
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| Length | 46 |
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| Name | Paneth cell-specific alpha-defensin 1 (DEFA1; horse defensin; houses, mammals, animals |
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| Source | Equus caballus (Horse) |
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| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal |
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| Pathogen | Gram-negative bacteria: Escherichia coli [ATCC 11775 (MBC=0.4 µM); ATCC 25922 (MBC=0.4 µM); ATCC 35218 (MBC=0.4 µM)], E. coli D31 (MBC=0.8 µM), Pseudomonas aeruginosa ATCC 11440 (MBC=3 µM);##Gram-positive bacteria: Staphylococcus aureus [ATCC 6538 (MBC=0.8 µM); ATCC 12600 (MBC=1.5 µM)], Staphylococcus epidermidis ATCC 14990 (MBC=1.5 µM), Enterococcus faecalis ATCC 29212 (MBC=6.1 µM), E. faecalis PEG 205 (wild-type) (MBC=3 µM), Streptococcus pyogenes ATCC 12344 (MBC=0.8 µM), Bacillus megaterium ATCC 14581 (MBC=0.2 µM).##Yeast: Candida albicans ATCC 24433 (MIC=0.8 µM). |
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| Hemolytic Activity | No hemolysis information or data found in the reference(s) presented in this entry |
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| Cytotoxicity | No cytotoxicity information found |
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| N-terminal Modification | Free |
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| C-terminal Modification | Free |
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| Linear/Cyclic/Branched | Cyclic |
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| Uniprot |
A6YB85 |
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| PDB |
2MXQ |
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| 3D View | |
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| PDB Download | Download PDB Predicted by Alphafold2 |
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| PubMed ID | 17620056 |
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